Community-based interventions for human papillomavirus (HPV) vaccination

Evidence Rating  
Some Evidence
Evidence rating: Some Evidence

Strategies with this rating are likely to work, but further research is needed to confirm effects. These strategies have been tested more than once and results trend positive overall.

Health Factors  
Decision Makers

Community-based interventions supporting HPV vaccination are usually multi-component, often combining information about HPV and the benefits of vaccinating against it with efforts to support vaccine initiation and series completion. Components may include community-wide education campaigns, outreach to specific populations, navigation support, referrals to vaccine providers, and vaccine provision. Community-based interventions take place in non-clinical, trusted community settings such as schools, and are provided by public health professionals, community health workers, or other trusted medical professionals.  

HPV vaccines protect against HPV and HPV-associated diseases, including some cancers. Vaccines are recommended for individuals ages 11-26 and are most effective in those who receive all doses and have no previous exposure to HPV1.

Expected Beneficial Outcomes (Rated)

  • Increased vaccination

Evidence of Effectiveness

There is some evidence that community-based interventions increase vaccination rates23, 4, 5. However, additional evidence is needed to confirm effects. 

School-based vaccine clinics can increase initiation among adolescent girls5. At a middle school in a medically underserved area, pairing a vaccine clinic with doctors providing education for parents, school nurses, staff, and other pediatric/family providers increased vaccination initiation and completion more than education alone2. Culturally competent multi-component interventions led by community health workers, called promotoras, may increase vaccine initiation3 and completion34, particularly among Mexican immigrants3. Culturally competent community forums may increase HPV knowledge in Black communities6. Community-based social marketing campaigns aimed at parents, done by county health departments in primarily rural areas, may increase vaccine initiation5.  

Parental reminders, through letters or text messaging, from non-clinical sources may increase HPV vaccine initiation or completion. For example, a study by the New York State Department of Health suggests that reminder letters sent to the parents or guardians of adolescents due for the first dose of the HPV vaccine appeared to increase vaccine initiation7. A small pilot study among parents attending the HealthWindow program at the New York City Mexican consulate suggests that HPV education in a trusted community setting and follow-up text message vaccination reminders may increase vaccine series completion8. In general, clinic or health care system-based reminder and recall systems (including telephone calls, letters, text messages, and outreach visits) can increase vaccine receipt59

Experts recommend using multiple strategies to increase HPV vaccination, including education, improved access to the vaccine, reminder and recall systems, and other clinic-based efforts1011. Provider recommendation of the vaccine increases acceptability12 and uptake1314

The National Association of County & City Health Officials (NACCHO) recommends coordination, collaboration and communication among public health, healthcare providers, parents and caregivers, and community partners at all levels to increase HPV vaccination15

Impact on Disparities

No impact on disparities likely

Implementation Examples

As of 2018, HPV vaccine administration is available at some schools in some states; for example, it is available at approximately one quarter of surveyed high schools in Delaware, but not at surveyed high schools in Hawaii or Pennsylvania16. The HPV vaccine is required for school attendance in Hawaii, Rhode Island, Virginia, and Washington DC17

Implementation Resources

CDC-Preteen and teen immunization resources - Centers for Disease Control and Prevention (CDC). Preteen and Teen Immunization Resources.


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1 CDC MMWR-Meites 2019 - Meites E, Szilagyi PG, Chesson HW, et al. Human Papillomavirus Vaccination for Adults: Updated Recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep 2019;68:698-702.

2 Kaul 2019 - Kaul S, Do TQN, Hsu E, et al. School-based human papillomavirus vaccination program for increasing vaccine uptake in an underserved area in Texas. Papillomavirus Research. 2019;8(September):100189.

3 Molokwu 2019* - Molokwu J, Dwivedi A, Mallawaarach I, Hernandez A, Shokar N. Tiempo de Vacunarte (time to get vaccinated): Outcomes of an intervention to improve HPV vaccination rates in a predominantly Hispanic community. Preventive Medicine. 2019;121(February):115-120.

4 Parra-Medina 2015 - Parra-Medina D, Morales-Campos DY, Mojica C, Ramirez AG. Promotora outreach, education and navigation support for HPV vaccination to Hispanic women with unvaccinated daughters. Journal of Cancer Education. 2015;30(2):353-359.

5 Niccolai 2015 - Niccolai LM, Hansen CE. Practice-and community-based interventions to increase human papillomavirus vaccine coverage: A systematic review. JAMA Pediatrics. 2015;169(7):686-692.

6 Teteh 2019 - Teteh DK, Dawkins-Moultin L, Robinson C, et al. Use of community forums to increase knowledge of HPV and cervical cancer in African American communities. Journal of Community Health. 2019;44(3):492-499.

7 Coley 2018* - Coley S, Hoefer D, Rausch-Phung E. A population‐based reminder intervention to improve human papillomavirus vaccination rates among adolescents at routine vaccination age. Vaccine. 2018;36(32):4904-4909.

8 Aragones 2015 - Aragones A, Bruno DM, Ehrenberg M, Tonda-Salcedo J, Gany FM. Parental education and text messaging reminders as effective community based tools to increase HPV vaccination rates among Mexican American children. Preventive Medicine Reports. 2015;2(2015):554-558.

9 Staras 2015 - Staras SAS, Vadaparampil ST, Livingston MD, et al. Increasing human papillomavirus vaccine initiation among publicly insured Florida adolescents. Journal of Adolescent Health. 2015;56(5):S40-S46.

10 Rodriguez 2019* - Rodriguez AM, Do TQN, Goodman M, et al. Human papillomavirus vaccine interventions in the US: A systematic review and meta-analysis. American Journal of Preventive Medicine. 2019;56(4):591-602.

11 Jacobson 2016 - Jacobson RM, Agunwamba AA, St. Sauver JL, Rutten LJF. The most effective and promising population health strategies to advance human papillomavirus vaccination. Expert Review of Vaccines. 2016;15(2):257-269.

12 Brewer 2007* - Brewer NT, Fazekas KI. Predictors of HPV vaccine acceptability: A theory-informed, systematic review. Preventive Medicine. 2007;45(2-3):107-14.

13 Kester 2013 - Kester LM, Zimet GD, Fortenberry JD, Kahn JA, Shew ML. A national study of HPV vaccination of adolescent girls: Rates, predictors, and reasons for non-vaccination. Maternal and Child Health Journal. 2014;17(5):879-885.

14 Kessels 2012* - Kessels SJ, Marshall HS, Watson M, et al. Factors associated with HPV vaccine uptake in teenage girls: A systematic review. Vaccine. 2012;30(24):3546-56.

15 NACCHO-HPV - National Association of County & City Health Officials (NACCHO). Statement of policy: Human papillomavirus. 2018.

16 CDC-School health profiles 2018 - Centers for Disease Control and Prevention (CDC). School health profiles 2018: Characteristics of health programs among secondary schools. Atlanta, Georgia. 2019.

17 NCSL-Skinner 2021 - Skinner E. Vaccine policy toolkit: Routine child vaccination. National Conference of State Legislatures (NCSL). 2021.

Date Last Updated